Publications

2008

Buening J, Homann N, Von Smolinski D, Borcherding F, Noack F, Stolte M, Kohl M, Lehnert H, Ludwig D. Helminths as Governors of Inflammatory Bowel Disease. Gut 2008.

Dittrich AM, Erbacher A, Specht S, Diesner F, Krokowski M, Avagyan A, Stock P, Ahrens B, Hoffmann WH, Hoerauf A and others. Helminth Infection with Litomosoides Sigmodontis Induces Regulatory T Cells and Inhibits Allergic Sensitization, Airway Inflammation, and Hyperreactivity in a Murine Asthma Model. J Immunol 2008; 180(3):1792-1799.

Schnoeller C, Rausch S, Pillai S, Avagyan A, Wittig BM, Loddenkemper C, Hamann A, Hamelmann E, Lucius R, Hartmann S. A Helminth Immunomodulator Reduces Allergic and Inflammatory Responses by Induction of IL-10-Producing Macrophages. J Immunol 2008; 180(6):4265-4272.

2007

Baumgart DC, Sandborn WJ. Inflammatory Bowel Disease: Clinical Aspects and Established and Evolving Therapies. Lancet 2007; 369(9573):1641-1657.

Baumgart DC, Carding SR. Inflammatory Bowel Disease: Cause and Immunobiology. Lancet 2007; 369(9573):1627-1640Correale J, Farez M. Association between Parasite Infection and Immune Responses in Multiple Sclerosis. Annals of Neurology 2007; 61(2):97-108.

Coyle P, Fishman P, Ford C, Fox E, Kirzinger S, Traboulsee A. Parasitism and Multiple Sclerosis Risk. Neura Perspectives on CNS Disease Management 2007; 7(3):1-5.

Elliott DE, Summers RW, Weinstock JV. Helminths as Governors of Immune-Mediated Inflammation. International Journal for Parasitology 2007; 37(5):457-464.

Hunter MM, Wang A, McKay DM. Helminth Infection Enhances Disease in a Murine TH2 Model of Colitis. Gastroenterology 2007; 132(4):1320-1330.

Korn T, Reddy J, Gao W, Bettelli E, Awasthi A, Petersen TR, Backstrom BT, Sobel RA, Wucherpfennig KW, Strom TB and Others. Myelin-Specific Regulatory T Cells Accumulate in the CNS but Fail to Control Autoimmune Inflammation. Nature Medicine 2007; 13(4):423-431.

Korn T, Oukka M. Dynamics of Antigen-Specific Regulatory T-Cells in the Context of Autoimmunity. Seminars in Immunology 2007; 19(4):272-278.
Loftus CG, Loftus EV, Jr., Harmsen WS, Zinsmeister AR, Tremaine WJ, Melton LJ, 3rd, Sandborn WJ. Update on the Incidence and Prevalence of Crohn's Disease and Ulcerative Colitis in Olmsted County, Minnesota, 1940-2000. Inflammatory Bowel Diseases 2007; 13(3):254-261.

Melendez AJ, Harnett MM, Pushparaj PN, Wong WS, Tay HK, McSharry CP, Harnett W. Inhibition of Fc Epsilon RI-Mediated Mast Cell Responses by ES-62, a Product of Parasitic Filarial Nematodes. Nature Medicine 2007; 13(11):1375-1381.

Mo HM, Liu WQ, Lei JH, Cheng YL, Wang CZ, Li YL. Schistosoma Japonicum Eggs Modulate the Activity of CD4+ CD25+ Tregs and Prevent Development of Colitis in Mice. Experimental Parasitology 2007; 116(4):385-389.

Setiawan T, Metwali A, Blum AM, Ince MN, Urban JF, Jr., Elliott DE, Weinstock JV. Heligmosomoides Polygyrus Promotes Regulatory T-Cell Cytokine Production in the Murine Normal Distal Intestine. Infection and Immunity 2007; 75(9):4655-4663.

Reddy A, Fried B. The Use of Trichuris Suis and Other Helminth Therapies to Treat Crohn's Disease. Parasitology Research 2007; 100(5):921-927.

Smith P, Mangan NE, Walsh CM, Fallon RE, McKenzie AN, Van Rooijen N, Fallon PG. Infection with a Helminth Parasite Prevents Experimental Colitis Via a Macrophage-Mediated Mechanism. J Immunol 2007; 178(7):4557-4566.

Trujillo-Vargas CM, Werner-Klein M, Wohlleben G, Polte T, Hansen G, Ehlers S, Erb KJ. Helminth-Derived Products Inhibit The Development of Allergic Responses in Mice. American Journal of Respiratory and Critical Care Medicine 2007; 175(4):336-344.

Van Kruiningen HJ, West AB. Iatrogenic Trichuris Suis Infection. Archives of Pathology & Laboratory Medicine 2007; 131(2):180.

Van Riet E, Hartgers FC, Yazdanbakhsh M. Chronic Helminth Infections Induce Immunomodulation: Consequences and Mechanisms. Immunobiology 2007; 212(6):475-490.

Yang J, Zhao J, Yang Y, Zhang L, Yang X, Zhu X, Ji M, Sun N, Su C. Schistosoma Japonicum Egg Antigens Stimulate CD4 CD25 T Cells and Modulate Airway Inflammation in a Murine Model of Asthma. Immunology 2007; 120(1):8-18.

2006

Asher MI, Montefort S, Bjorksten B, Lai CK, Strachan DP, Weiland SK, Williams H. Worldwide Time Trends In The Prevalence Of Symptoms of Asthma, Allergic Rhinoconjunctivitis, and Eczema in Childhood: ISAAC Phases One and Three Repeat Multicountry Cross-Sectional Surveys. Lancet 2006; 368(9537):733-743.

Carvalho EM, Bastos LS, Araujo MI. Worms and Allergy. Parasite Immunology 2006; 28(10):525-534.

Flohr C, Tuyen LN, Lewis S, Quinnell R, Minh TT, Liem HT, Campbell J, Pritchard D, Hien TT, Farrar J And Others. Poor Sanitation and Helminth Infection Protect Against Skin Sensitization in Vietnamese Children: A Cross-Sectional Study. The Journal of Allergy and Clinical Immunology 2006; 118(6):1305-1311.

Ince MN, Elliott DE, Setiawan T, Blum A, Metwali A, Wang Y, Urban JF, Jr., Weinstock JV. Heligmosomoides Polygyrus Induces TLR4 on Murine Mucosal T Cells that Produce Tgfbeta after Lipopolysaccharide Stimulation. J Immunol 2006; 176(2):726-729.

Kitagaki K, Businga TR, Racila D, Elliott DE, Weinstock JV, Kline JN. Intestinal Helminths Protect in a Murine Model of Asthma. J Immunol 2006; 177(3):1628-1635

Kradin RL, Badizadegan K, Auluck P, Korzenik J, Lauwers GY. Iatrogenic Trichuris Suis Infection in a Patient with Crohn Disease. Archives of Pathology & Laboratory Medicine 2006; 130(5):718-720.

Kringel H, Roepstorff A. Trichuris Suis Population Dynamics Following a Primary Experimental Infection. Vet Parasitol 2006; 139(1-3):132-139.

Kringel H, Iburg T, Dawson H, Aasted B, Roepstorff A. A Time Course Study Of Immunological Responses in Trichuris Suis Infected Pigs Demonstrates Induction of a Local Type 2 Response Associated with Worm Burden. International Journal for Parasitology 2006; 36(8):915-924.

Leonardi-Bee J, Pritchard D, Britton J. Asthma and Current Intestinal Parasite Infection: Systematic Review and Meta-Analysis. American Journal of Respiratory and Critical Care Medicine 2006; 174(5):514-523.

Mangan NE, Van Rooijen N, Mckenzie AN, Fallon PG. Helminth-Modified Pulmonary Immune Response Protects Mice from Allergen-Induced Airway Hyperresponsiveness. J Immunol 2006; 176(1):138-147.

Metwali A, Setiawan T, Blum AM, Urban J, Elliott DE, Hang L, Weinstock JV. Induction of CD8+ Regulatory T Cells in the Intestine by Heligmosomoides Polygyrus Infection. Am J Physiol Gastrointest Liver Physiol 2006; 291(2):G253-259.

Reddy JG, Loftus EV, Jr. Safety of Infliximab and other Biologic Agents in the Inflammatory Bowel Diseases. Gastroenterology Clinics of North America 2006; 35(4):837-855.

Sands BE. New Therapies for the Treatment of Inflammatory Bowel Disease. The Surgical Clinics of North America 2006; 86(4):1045-1064.

Seddiki N, Santner-Nanan B, Tangye SG, Alexander SI, Solomon M, Lee S, Nanan R, Fazekas De Saint Groth B. Persistence of Naive CD45RA+ Regulatory T Cells in Adult Life. Blood 2006; 107(7):2830-2838

Seddiki N, Santner-Nanan B, Martinson J, Zaunders J, Sasson S, Landay A, Solomon M, Selby W, Alexander SI, Nanan R and Others. Expression Of Interleukin (IL)-2 And IL-7 Receptors Discriminates Between Human Regulatory and Activated T Cells. The Journal of Experimental Medicine 2006; 203(7):1693-1700.

Summers RW, Elliott DE, Weinstock JV. Therapeutic Colonization with Trichuris Suis. Archives of Pathology & Laboratory Medicine 2006; 130(12):1753; Author Reply 1753-1754.

Yonekawa K, Harlan JM. Targeting Leukocyte Integrins in Human Diseases. Journal of Leukocyte Biology 2005; 77(2):129-140.

Zaccone P, Fehervari Z, Phillips JM, Dunne DW, Cooke A. Parasitic Worms and Inflammatory Diseases. Parasite Immunology 2006; 28(10):515-523.

2005

Bernstein CN, Wajda A, Blanchard JF. The Clustering of other Chronic Inflammatory Diseases in Inflammatory Bowel Disease: A Population-Based Study. Gastroenterology 2005; 129(3):827-836

Cabre P, Signate A, Olindo S, Merle H, Caparros-Lefebvre D, Bera O, Smadja D. Role of Return Migration in the Emergence of Multiple Sclerosis in the French West Indies. Brain 2005; 128(Pt 12):2899-2910.

Dunne DW, Cooke A. A Worm's Eye View of the Immune System: Consequences for Evolution of Human Autoimmune Disease. Nature Reviews 2005; 5(5):420-426.

Eldeirawi K, McConnell R, Freels S, Persky VW. Associations of Place of Birth with Asthma and Wheezing In Mexican American Children. The Journal of Allergy and Clinical Immunology 2005; 116(1):42-48.

Elliott DE, Summers RW, Weinstock JV. Helminths and the Modulation of Mucosal Inflammation. Current Opinion in Gastroenterology 2005; 21(1):51-58

Elliott AM, Mpairwe H, Quigley MA, Nampijja M, Muhangi L, Oweka-Onyee J, Muwanga M, Ndibazza J, Whitworth JA. Helminth Infection during Pregnancy and Development of Infantile Eczema. Jama 2005; 294(16):2032-2034.

Falcone FH, Pritchard DI. Parasite Role Reversal: Worms on Trial. Trends in Parasitology 2005; 21(4):157-160.

Gupta G, Gelfand JM, Lewis JD. Increased Risk For Demyelinating Diseases In Patients With Inflammatory Bowel Disease. Gastroenterology 2005; 129(3):819-826.

Heitmann K, M. Ce, Iven E, Bachmann H, Hanisch P. Successful Helminthic Therapy of Previously Therapy-Resistant Eosinophilic Colitis. Ovamed, Barsbüttel, Germany 2005; Therapy Poster, Gesundheit Nord Klinikum Links Der Weser(Department of Pediatric Gastroenterology, Hospital for Pediatric and Youth Medicine, Hospital Links Der Weser, Bremen, Germany * Institute for Pathology, Hospital Bremen-Mitte).

Hunter MM, Wang A, Hirota CL, Mckay DM. Neutralizing Anti-IL-10 Antibody Blocks The Protective Effect of Tapeworm Infection in a Murine Model of Chemically Induced Colitis. J Immunol 2005; 174(11):7368-7375.

Isaacs KL, Lewis JD, Sandborn WJ, Sands BE, Targan SR. State of the Art: IBD Therapy and Clinical Trials in IBD. Inflammatory Bowel Diseases 2005; 11 Suppl 1:S3-12.

Korzenik JR, Dieckgraefe BK, Valentine JF, Hausman DF, Gilbert MJ. Sargramostim for Active Crohn's Disease. The New England Journal of Medicine 2005; 352(21):2193-2201.

Korzenik JR. Past and Current Theories of Etiology of IBD: Toothpaste, Worms, and Refrigerators. Journal of Clinical Gastroenterology 2005; 39(4 Suppl 2):S59-60.

Maizels RM. Infections and Allergy - Helminths, Hygiene and Host Immune Regulation. Current Opinion in Immunology 2005; 17(6):656-661.

Moreels TG, Pelckmans PA. Gastrointestinal Parasites: Potential Therapy, for Refractory Inflammatory Bowel Diseases. Inflammatory Bowel Diseases 2005; 11(2):178-184

Pardi DS, Sandborn WJ. Predicting Relapse in Patients with Inflammatory Bowel Disease: What is the Role of Biomarkers? Gut 2005; 54(3):321-322.

Parthasarathy G, Mansfield LS. Trichuris Suis Excretory Secretory Products (ESP) Elicit Interleukin-6 (IL-6) and IL-10 Secretion from Intestinal Epithelial Cells (IPEC-1). Vet Parasitol 2005; 131(3-4):317-324.

Ponsonby AL, Van Der Mei I, Dwyer T, Blizzard L, Taylor B, Kemp A, Simmons R, Kilpatrick T. Exposure To Infant Siblings During Early Life and Risk of Multiple Sclerosis. Jama 2005; 293(4):463-469.

Robuck PR, Wurzelmann JI. Understanding the Drug Development Process. Inflammatory Bowel Diseases 2005; 11 Supply 1:S13-16.

Sands BE, Abreu MT, Ferry GD, Griffiths AM, Hanauer SB, Isaacs KL, Lewis JD, Sandborn WJ, Steinhart AH. Design Issues and Outcomes in IBD Clinical Trials. Inflammatory Bowel Diseases 2005; 11 Suppl 1:S22-28.

Summers RW, Elliott DE, Urban JF, Jr., Thompson RA, Weinstock JV. Trichuris Suis Therapy for Active Ulcerative Colitis: A Randomized Controlled Trial. Gastroenterology 2005; 128(4):825-832.

Summers RW, Elliott DE, Weinstock JV. Why Trichuris Suis Should Prove Safe for Use in Inflammatory Bowel Diseases. Inflammatory Bowel Diseases 2005; 11(8):783-784.

Summers RW, Elliott DE, Weinstock JV. Is There a Role for Helminths in the Therapy of Inflammatory Bowel Disease? Nature Clinical Practice 2005; 2(2):62-63.

Summers RW, Elliott DE, Urban JF, Jr., Thompson R, Weinstock JV. Trichuris Suis Therapy in Crohn's Disease. Gut 2005; 54(1):87-90.

Tremaine WJ, Carlson MR, Isaacs KL, Motil KJ, Robuck PR, Wurzelmann JI. Ethical Issues, Safety, and Data Integrity in Clinical Trials. Inflammatory Bowel Diseases 2005; 11 Suppl 1:S17-21.

Van Kruiningen HJ, A.B. W. Potential Danger in the Medical Use of Trichuris Suis for the Treatment of Inflammatory Bowel Disease (Comment). InflammatoryBowel Diseases 2005; 11(5):515.

Weinstock JV, Summers RW, Elliott DE. Role of Helminths in Regulating Mucosal Inflammation. Springer Seminars in Immunopathology 2005; 27(2):249-271.

Wilson MS, Taylor MD, Balic A, Finney CA, Lamb JR, Maizels RM. Suppression of Allergic Airway Inflammation by Helminth-Induced Regulatory T Cells. The Journal of Experimental Medicine 2005; 202(9):1199-1212.

Wolf DC, Katz S, Safdi MA, Sandler RS, Lewis JD. Site Organization and Management. Inflammatory Bowel Diseases 2005; 11 Suppl 1:S29-33.

2004

Araujo MI, Hoppe BS, Medeiros M, Jr., Carvalho EM. Schistosoma Mansoni Infection Modulates the Immune Response Against Allergic and Auto-Immune Diseases. Memorias Do Instituto Oswaldo Cruz 2004; 99(5 Suppl 1):27-32.

Borkow G, Bentwich Z. Chronic Immune Activation Associated With Chronic Helminthic and Human Immunodeficiency Virus Infections: Role of Hyporesponsiveness and Anergy. Clinical Microbiology Reviews 2004; 17(4):1012-1030.

Elliott DE, Setiawan T, Metwali A, Blum A, Urban JF, Jr., Weinstock JV. Heligmosomoides Polygyrus Inhibits Established Colitis In IL-10-Deficient Mice. European Journal of Immunology 2004; 34(10):2690-2698.

Hunter MM, McKay DM. Review Article: Helminths as Therapeutic Agents for Inflammatory Bowel Disease. Alimentary Pharmacology & Therapeutics 2004; 19(2):167-177.

Korn T, Muller R, Kontermann RE. Bispecific Single-Chain Diabody-Mediated Killing of Endoglin-Positive Endothelial Cells by Cytotoxic T Lymphocytes. J Immunother 2004; 27(2):99-106.

Loftus EV, Jr. Clinical Epidemiology of Inflammatory Bowel Disease: Incidence, Prevalence, and Environmental Influences. Gastroenterology 2004; 126(6):1504-1517.

Maizels RM, Balic A, Gomez-Escobar N, Nair M, Taylor MD, Allen JE. Helminth Parasites--Masters of Regulation. Immunological Reviews 2004; 201:89-116.

Mangan NE, Fallon RE, Smith P, Van Rooijen N, Mckenzie AN, Fallon PG. Helminth Infection Protects Mice from Anaphylaxis Via IL-10-Producing B Cells. J Immunol 2004; 173(10):6346-6356.

Marrie RA. Environmental Risk Factors in Multiple Sclerosis Aetiology. Lancet Neurology 2004; 3(12):709-718.

Moreels TG, Nieuwendijk RJ, De Man JG, De Winter BY, Herman AG, Van Marck EA, Pelckmans PA. Concurrent Infection with Schistosoma Mansoni Attenuates Inflammation Induced Changes in Colonic Morphology, Cytokine Levels, and Smooth Muscle Contractility of Trinitrobenzene Sulphonic Acid Induced Colitis in Rats. Gut 2004; 53(1):99-107.

Nookala S, Srinivasan S, Kaliraj P, Narayanan RB, Nutman TB. Impairment of Tetanus-Specific Cellular and Humoral Responses Following Tetanus Vaccination in Human Lymphatic Filariasis. Infection and Immunity 2004; 72(5):2598-2604.

Schubert C. The Worm Has Turned. Nature Medicine 2004; 10(12):1271-1272.

Shin JL, Gardiner GW, Deitel W, Kandel G. Does Whipworm Increase the Pathogenicity of Campylobacter Jejuni? A Clinical Correlate of an Experimental Observation. Canadian Journal of Gastroenterology 2004; 18(3):175-177.

Summers R, Elliott D, Weinstock J. Trichuris Suis In The Therapy Of Inflammatory Bowel Disease: Summary of Two Clinical Studies Conducted in The Center for Digestive Diseases at the University of Iowa. University of Iowa Health Care 2004:1-6

Van Den Biggelaar AH, Rodrigues LC, Van Ree R, Van Der Zee JS, Hoeksma-Kruize YC, Souverijn JH, Missinou MA, Borrmann S, Kremsner PG, Yazdanbakhsh M. Long-Term Treatment of Intestinal Helminths Increases Mite Skin-Test Reactivity in Gabonese Schoolchildren. J Infect Dis 2004; 189(5):892-900.

Weinstock JV, Summers R, Elliott DE. Helminths and Harmony. Gut 2004; 53(1):7-9.

Wickelgren I. Immunotherapy. Can Worms Tame the Immune System? Science (New York, NY 2004; 305(5681):170-171.

Wilson MS, Maizels RM. Regulation of Allergy and Autoimmunity in Helminth Infection. Clinical Reviews in Allergy & Immunology 2004; 26(1):35-50.

Wohlleben G, Trujillo C, Muller J, Ritze Y, Grunewald S, Tatsch U, Erb KJ. Helminth Infection Modulates the Development of Allergen-Induced Airway Inflammation. International Immunology 2004; 16(4):585-596.

2003

Cooper PJ, Chico ME, Rodrigues LC, Ordonez M, Strachan D, Griffin GE, Nutman TB. Reduced Risk of Atopy Among School-Age Children Infected with Geohelminth Parasites in a Rural Area of the Tropics. The Journal of Allergy and Clinical Immunology 2003; 111(5):995-1000.

Elliott DE, Li J, Blum A, Metwali A, Qadir K, Urban JF, Jr., Weinstock JV. Exposure to Schistosome Eggs Protects Mice from TNBS-Induced Colitis. Am J Physiol Gastrointest Liver Physiol 2003; 284(3):G385-391.

Ghosh S. Alpha4 Integrin Blockade in Inflammatory Bowel Disease. Annals of the Rheumatic Diseases 2003; 62 Suppl 2:Ii70-72.

Ghosh S, Goldin E, Gordon FH, Malchow HA, Rask-Madsen J, Rutgeerts P, Vyhnalek P, Zadorova Z, Palmer T, Donoghue S. Natalizumab. For Active Crohn's Disease. The New England Journal of Medicine 2003; 348(1):24-32.

Halfvarson J, Bodin L, Tysk C, Lindberg E, Jarnerot G. Inflammatory Bowel Disease in a Swedish Twin Cohort: A Long-Term Follow-Up of Concordance and Clinical Characteristics. Gastroenterology 2003; 124(7):1767-1773.

Irvine EJ, Satsangi J, Sutherland L, Colombel JF, Fiocchi C, Lofberg R, Pemberton J, Rugeerts P. Assesing Outcomes in Clinical Trials. Inflammatory Bowel Diseases 2003:319-333.

La Flamme AC, Ruddenklau K, Backstrom BT. Schistosomiasis Decreases Central Nervous System Inflammation and Alters the Progression of Experimental Autoimmune Encephalomyelitis. Infection and Immunity 2003; 71(9):4996-5004.

McInnes IB, Leung BP, Harnett M, Gracie JA, Liew FY, Harnett W. A Novel Therapeutic Approach Targeting Articular Inflammation Using the Filarial Nematode-Derived Phosphorylcholine-Containing Glycoprotein ES-62. J Immunol 2003;171(4):2127-2133.

Maizels RM, Yazdanbakhsh M. Immune Regulation by Helminth Parasites: Cellular and Molecular Mechanisms. Nature Reviews 2003; 3(9):733-744.

Mansfield LS, Gauthier DT, Abner SR, Jones KM, Wilder SR, Urban JF. Enhancement of Disease and Pathology by Synergy of Trichuris Suis and Campylobacter Jejuni in the Colon of Immunologically Naive Swine. The American Journal of Tropical Medicine and Hygiene 2003; 68(1):70-80.

Medeiros M, Jr., Figueiredo JP, Almeida MC, Matos MA, Araujo MI, Cruz AA, Atta AM, Rego MA, De Jesus AR, Taketomi EA and others. Schistosoma Mansoni Infection is Associated with a Reduced Course of Asthma. The Journal of Allergy and Clinical Immunology 2003; 111(5):947-951.

Sewell D, Qing Z, Reinke E, Elliot D, Weinstock J, Sandor M, Fabry Z. Immunomodulation of Experimental Autoimmune Encephalomyelitis by Helminth Ova Immunization. International Immunology 2003; 15(1):59-69.

Sewell DL, Reinke EK, Co DO, Hogan LH, Fritz RB, Sandor M, Fabry Z. Infection with Mycobacterium Bovis BCG Diverts Traffic of Myelin Oligodendroglial Glycoprotein Autoantigen-Specific T Cells Away from the Central Nervous System and Ameliorates Experimental Autoimmune Encephalomyelitis. Clinical and Diagnostic Laboratory Immunology 2003; 10(4):564-572

Summers RW, Elliott DE, Qadir K, Urban JF, Jr., Thompson R, Weinstock JV. Trichuris Suis Seems to be Safe and Possibly Effective in the Treatment of Inflammatory Bowel Disease. The American Journal of Gastroenterology 2003; 98(9):2034-2041.

Summers R, Elliott DE, Thompson R. Helminths and the Modulation of Mucosal Inflammation. World J Gastroenterol 2003; 10:404-409.

Von Andrian UH, Engelhardt B. Alpha4 Integrins as Therapeutic Targets in Autoimmune Disease. The New England Journal of Medicine 2003; 348(1):68-72.

Zaccone P, Fehervari Z, Jones FM, Sidobre S, Kronenberg M, Dunne DW, Cooke A. Schistosoma Mansoni Antigens Modulate The Activity of the Innate Immune Response and Prevent Onset of Type 1 Diabetes. European Journal of Immunology 2003; 33(5):1439-1449.

2002

Bach JF. The Effect of Infections on Susceptibility to Autoimmune and Allergic Diseases. The New England Journal of Medicine 2002; 347(12):911-920.

Bashir ME, Andersen P, Fuss IJ, Shi HN, Nagler-Anderson C. An Enteric Helminth Infection Protects Against an Allergic Response to Dietary Antigen. J Immunol 2002; 169(6):3284-3292.

Gale EA. A Missing Link in the Hygiene Hypothesis? Diabetologia 2002; 45(4):588-594.

Hanauer SB, Feagan BG, Lichtenstein GR, Mayer LF, Schreiber S, Colombel JF, Rachmilewitz D, Wolf DC, Olson A, Bao W and others. Maintenance Infliximab for Crohn's Disease: The ACCENT I Randomised Trial. Lancet 2002; 359(9317):1541-1549

Huang SL, Tsai PF, Yeh YF. Negative Association of Enterobius Infestation with Asthma and Rhinitis in Primary School Children in Taipei. Clin Exp Allergy 2002; 32(7):1029-1032.

Khan WI, Blennerhasset PA, Varghese AK, Chowdhury SK, Omsted P, Deng Y, Collins SM. Intestinal Nematode Infection Ameliorates Experimental Colitis in Mice. Infection and Immunity 2002; 70(11):5931-5937.

Perzanowski MS, Ng'ang'a LW, Carter MC, Odhiambo J, Ngari P, Vaughan JW, Chapman MD, Kennedy MW, Platts-Mills TA. Atopy, Asthma, and Antibodies to Ascaris among Rural and Urban Children in Kenya. The Journal of Pediatrics 2002; 140(5):582-588.

Sewell DL, Reinke EK, Hogan LH, Sandor M, Fabry Z. Immunoregulation of CNS Autoimmunity by Helminth and Mycobacterial Infections. Immunol Lett 2002; 82(1-2):101-110.

Van Assche G, Rutgeerts P. Antiadhesion Molecule Therapy in Inflammatory Bowel Disease. Inflammatory Bowel Diseases 2002; 8(4):291-300

Weinstock JV, Summers RW, Elliott DE, Qadir K, Urban JF, Jr., Thompson R. The Possible Link between De-Worming and the Emergence of Immunological Disease. The Journal of Laboratory and Clinical Medicine 2002; 139(6):334-338.

Yazdanbakhsh M, Kremsner PG, Van Ree R. Allergy, Parasites, and the Hygiene Hypothesis. Science (New York, NY 2002; 296(5567):490-494.

2001

Abner SR, Parthasarathy G, Hill DE, Mansfield LS. Trichuris Suis: Detection of Antibacterial Activity in Excretory-Secretory Products from Adults. Experimental Parasitology 2001; 99(1):26-36.

Bo X, Broome U, Remberger M, Sumitran-Holgersson S. Tumour Necrosis Factor Alpha Impairs Function of Liver Derived T Lymphocytes and Natural Killer Cells In Patients With Primary Sclerosing Cholangitis. Gut 2001; 49(1):131-1

Cooke A, Phillips JM, Parish NM. Tolerogenic Strategies to Halt or Prevent Type 1 Diabetes. Nature Immunology 2001; 2(9):810-815.

Hanauer SB, Sandborn W. Management of Crohn's Disease in Adults. The American Journal of Gastroenterology 2001; 96(3):635-643.

Markus MB, Fincham JE. Implications for Neonatal HIV/AIDS and TB of Sensitization in Utero to Helminths. Trends in Parasitology 2001; 17(1):8.

Neurath MF, Finotto S, Fuss I, Boirivant M, Galle PR, Strober W. Regulation of T-Cell Apoptosis in Inflammatory Bowel Disease: To Die or Not to Die, That is the Mucosal Question. Trends in Immunology 2001; 22(1):21-26.

Pritchard DI, Brown A. Is Necator Americanus Approaching A Mutualistic Symbiotic Relationship with Humans? Trends in Parasitology 2001; 17(4):169-172.

Reardon C, Sanchez A, Hogaboam CM, McKay DM. Tapeworm Infection Reduces Epithelial Ion Transport Abnormalities in Murine Dextran Sulfate Sodium-Induced Colitis. Infection and Immunity 2001; 69(7):4417-4423.

Scrivener S, Yemaneberhan H, Zebenigus M, Tilahun D, Girma S, Ali S, Mcelroy P, Custovic A, Woodcock A, Pritchard D and others. Independent Effects of Intestinal Parasite Infection and Domestic Allergen Exposure on Risk of Wheeze in Ethiopia: A Nested Case-Control Study. Lancet 2001; 358(9292):1493-1499.

Van Den Biggelaar AH, Lopuhaa C, Van Ree R, Van Der Zee JS, Jans J, Hoek A, Migombet B, Borrmann S, Luckner D, Kremsner PG and others. The Prevalence of Parasite Infestation and House Dust Mite Sensitization in Gabonese Schoolchildren. International Archives of Allergy and Immunology 2001; 126(3):231-238.

Wang CC, Nolan TJ, Schad GA, Abraham D. Infection of Mice with the Helminth Strongyloides Stercoralis Suppresses Pulmonary Allergic Responses to Ovalbumin. Clin Exp Allergy 2001; 31(3):495-503.

2000

Alic M. Crohn's Disease Epidemiology at the Turn of the Century-Solving the Puzzle. The American Journal of Gastroenterology 2000; 95(1):321-323.

Borkow G, Leng Q, Weisman Z, Stein M, Galai N, Kalinkovich A, Bentwich Z. Chronic Immune Activation Associated with Intestinal Helminth Infections Results in Impaired Signal Transduction and Anergy. The Journal of Clinical Investigation 2000; 106(8):1053-1060

Doetze A, Satoguina J, Burchard G, Rau T, Loliger C, Fleischer B, Hoerauf A. Antigen-Specific Cellular Hyporesponsiveness in a Chronic Human Helminth Infection is Mediated by T(H)3/T(R)1-Type Cytokines IL-10 and Transforming Growth Factor-Beta but not by a T(H)1 To T(H)2 Shift. International Immunology 2000; 12(5):623-630.

Elliott DE, Urban JJ, Argo CK, Weinstock JV. Does the Failure to Acquire Helminthic Parasites Predispose to Crohn's Disease? FSAB J 2000; 14(12):1848-1855

Pedersen S, Saeed I. Experimental Infection of Pigs with Three Dose Levels of Trichuris Suis. Parasite (Paris, France) 2000; 7(4):275-281

Van Den Biggelaar AH, Van Ree R, Rodrigues LC, Lell B, Deelder AM, Kremsner PG, Yazdanbakhsh M. Decreased Atopy In Children Infected With Schistosoma Haematobium: A Role For Parasite-Induced Interleukin-10. Lancet 2000; 356(9243):1723-1727

1999

Arndt MA, Krauss J, Kipriyanov SM, Pfreundschuh M, Little M. A Bispecific Diabody That Mediates Natural Killer Cell Cytotoxicity against Xenotransplantated Human Hodgkin's Tumors. Blood 1999; 94(8):2562-2568.

Carr I, Mayberry JF. The Effects of Migration on Ulcerative Colitis: A Three-Year Prospective Study among Europeans and First- and Second- Generation South Asians in Leicester (1991-1994). The American Journal of Gastroenterology 1999; 94(10):2918-2922.

Cooke A, Tonks P, Jones FM, O'Shea H, Hutchings P, Fulford AJ, Dunne DW. Infection with Schistosoma Mansoni Prevents Insulin Dependent Diabetes Mellitus In Non-Obese Diabetic Mice. Parasite Immunology 1999; 21(4):169-176.

Finkelman FD, Wynn TA, Donaldson DD, Urban JF. The Role of IL-13 in Helminth-Induced Inflammation and Protective Immunity against Nematode Infections. Current Opinion in Immunology 1999; 11(4):420-426.

Malhotra I, Mungai P, Wamachi A, Kioko J, Ouma JH, Kazura JW, King CL. Helminth- and Bacillus Calmette-Guerin-Induced Immunity in Children Sensitized in Utero to Filariasis and Schistosomiasis. J Immunol 1999; 162(11):6843-6848.

Onkamo P, Vaananen S, Karvonen M, Tuomilehto J. Worldwide Increase in Incidence of Type I Diabetes--The Analysis Of The Data On Published Incidence Trends. Diabetologia 1999; 42(12):1395-1403.

1998

Delco F, Sonnenberg A. Military History of Patients with Inflammatory Bowel Disease: An Epidemiological Study among U.S. Veterans. The American Journal of Gastroenterology 1998; 93(9):1457-1462.

Panes J, Granger DN. Leukocyte-Endothelial Cell Interactions: Molecular Mechanisms and Implications in Gastrointestinal Disease. Gastroenterology 1998; 114(5):1066-1090.

Walmsley RS, Ayres RC, Pounder RE, Allan RN. A Simple Clinical Colitis Activity Index. Gut 1998; 43(1):29-32

Wize J, Sopata I, Smerdel A, Maslinski S. Ligation of Selectin L and Integrin CD11b/CD18 (Mac-1) Induces Release of Gelatinase B (MMP-9) from Human Neutrophils. Inflamm Res 1998; 47(8):325-327.

1997

Ilnyckyj A, Shanahan F, Anton PA, Cheang M, Bernstein CN. Quantification of the Placebo Response in Ulcerative Colitis. Gastroenterology 1997; 112(6):1854-1858.

Hanauer SB, Meyers S. Management of Crohn's Disease in Adults. The American Journal of Gastroenterology 1997; 92(4):559-566.

1996

Bentwich Z, Weisman Z, Moroz C, Bar-Yehuda S, Kalinkovich A. Immune Dysregulation in Ethiopian Immigrants in Israel: Relevance to Helminth Infections? Clinical and Experimental Immunology 1996; 103(2):239-243.

Hanauer SB. Inflammatory Bowel Disease. The New England Journal of Medicine 1996; 334(13):841-848

Mansfield LS, Urban JF, Jr. The Pathogenesis of Necrotic Proliferative Colitis in Swine Is Linked To Whipworm Induced Suppression of Mucosal Immunity to Resident Bacteria. Veterinary Immunology and Immunopathology 1996; 50(1-2):1-17.

Sabin EA, Araujo MI, Carvalho EM, Pearce EJ. Impairment of Tetanus Toxoid-Specific Th1-Like Immune Responses in Humans Infected with Schistosoma Mansoni. J Infect Dis 1996; 173(1):269-272.

1995

Jones SC, Banks RE, Haidar A, Gearing AJ, Hemingway IK, Ibbotson SH, Dixon MF, Axon AT. Adhesion Molecules in Inflammatory Bowel Disease. Gut 1995; 36(5):724-730.

Lynch JJ, 3rd, Yu SP, Canzoniero LM, Sensi SL, Choi DW. Sodium Channel Blockers Reduce Oxygen-Glucose Deprivation-Induced Cortical Neuronal Injury when Combined with Glutamate Receptor Antagonists. The Journal of Pharmacology and Experimental Therapeutics 1995; 273(1):554-560.

Seo M, Okada M, Yao T, Okabe N, Maeda K, Oh K. Evaluation of Disease Activity in Patients with Moderately Active Ulcerative Colitis: Comparisons between a New Activity Index and Truelove and Witts' Classification. The American Journal of Gastroenterology 1995; 90(10):1759-1763.

1994

Gent AE, Hellier MD, Grace RH, Swarbrick ET, Coggon D. Inflammatory Bowel Disease and Domestic Hygiene in Infancy. Lancet 1994; 343(8900):766-767.

Arndt H, Palitzsch KD, Anderson DC, Rusche J, Grisham MB, Granger DN. Leucocyte-Endothelial Cell Adhesion in a Model of Intestinal Inflammation. Gut 1995; 37(3):374-379.

1993

Ferrari AP, Camacho L, Chehter L, Parisi FH, Geocze S. Severe Whipworm Infestation: A Rare Cause Of Inflammatory Dysenteric Bowel Disease. Endoscopy 1993; 25(8):549-550.

Hill DE, Gamble HR, Rhoads ML, Fetterer RH, Urban JF, Jr. Trichuris Suis: A Zinc Metalloprotease from Culture Fluids of Adult Parasites. Experimental Parasitology 1993; 77(2):170-178.

Lynch NR, Hagel I, Perez M, Di Prisco MC, Lopez R, Alvarez N. Effect of Anthelmintic Treatment on the Allergic Reactivity of Children in a Tropical Slum. The Journal of Allergy and Clinical Immunology 1993; 92(3):404-411.

Maizels RM, Bundy DA, Selkirk ME, Smith DF, Anderson RM. Immunological Modulation and Evasion by Helminth Parasites in Human Populations. Nature 1993; 365(6449):797-805.

Mishra L, Mishra BB, Harris M, Bayless TM, Muchmore AV. In Vitro Cell Aggregation and Cell Adhesion Molecules in Crohn's Disease. Gastroenterology 1993; 104(3):772-779

Ooi HK, Tenora F, Itoh K, Kamiya M. Comparative Study Of Trichuris Trichiura From Non-Human Primates And From Man, And Their Difference With T. Suis. The Journal of Veterinary Medical Science / The Japanese Society of Veterinary Science 1993; 55(3):363-366.

Pearlman E, Kazura JW, Hazlett FE, Jr., Boom WH. Modulation of Murine Cytokine Responses to Mycobacterial Antigens by Helminth-Induced T Helper 2 Cell Responses. J Immunol 1993; 151(9):4857-4864.

Podolsky DK, Lobb R, King N, Benjamin CD, Pepinsky B, Sehgal P, Debeaumont M. Attenuation Of Colitis In The Cotton-Top Tamarin By Anti-Alpha4 Integrin Monoclonal Antibody. The Journal of Clinical Investigation 1993; 92(1):372-380.

1992

Kullberg MC, Pearce EJ, Hieny SE, Sher A, Berzofsky JA. Infection with Schistosoma Mansoni Alters Th1/Th2 Cytokine Responses to a Non-Parasite Antigen. J Immunol 1992; 148(10):3264-3270.

Seo M, Okada M, Yao T, Ueki M, Arima S, Okumura M. An Index of Disease Activity in Patients with Ulcerative Colitis. The American Journal of Gastroenterology 1992; 87(8):971-976

Urban JF, Jr., Madden KB, Svetic A, Cheever A, Trotta PP, Gause WC, Katona IM, Finkelman FD. The Importance of Th2 Cytokines in Protective Immunity to Nematodes. Immunological Reviews 1992; 127:205-220.

1990

Sonnenberg A. Occupational Distribution of Inflammatory Bowel Disease among German Employees. Gut 1990; 31(9):1037-1040.

1987

Schroeder KW, Tremaine WJ, Ilstrup DM. Coated Oral 5-Aminosalicylic Acid Therapy For Mildly To Moderately Active Ulcerative Colitis. A Randomized Study. The New England Journal of Medicine 1987; 317(26):1625-1629.

1986

Calkins BM, Mendeloff AI. Epidemiology of Inflammatory Bowel Disease. Epidemiologic Reviews 1986; 8:60-91.

1984

Fort FL, Heyman IA, Kesterson JW. Hemolysis Study of Aqueous Polyethylene Glycol 400, Propylene Glycol and Ethanol Combinations In Vivo and In Vitro. J Parenter Sci Technol 1984; 38(2):82-87.

1978

Beer RJ. The Relationship between Trichuris Trichiura (Linnaeus 1758) of Man and Trichuris Suis (Schrank 1788) of the Pig. Res Vet Sci 1976; 20(1):47-54.

Powell-Tuck J, Bown RL, Lennard-Jones JE. A Comparison of Oral Prednisolone Given As Single or Multiple Daily Doses for Active Proctocolitis. Scandinavian Journal of Gastroenterology 1978; 13(7):833-837.

1975

Hubbard DW, Morgan PM, Yaeger RG, Unglaub WG, Hood MW, Willis RA. Intestinal Parasite Survey of Kindergarten Children in New Orleans. Pediatric Research 1974; 8(6):652-658.

Rutter JM, Beer RJ. Synergism between Trichuris Suis and the Microbial Flora of the Large Intestine Causing Dysentery in Pigs. Infection and Immunity 1975; 11(2):395-404.

1973

Beer RJ. Morphological Descriptions of the Egg and Larval Stages of Trichuris Suis Schrank, 1788. Parasitology 1973; 67(3):263-278.

Beer RJ. Studies on the Biology of the Life-Cycle of Trichuris Suis Schrank, 1788. Parasitology 1973; 67(3):253-262.

1970

Henry VG, Conley RH. Some Parasites of European Wild Hogs in the Southern Appalachians the Journal of Wildlife Management 1970; 34(4):913-917.